Markus Fischer Selected Research

6,7-dimethyl-8-ribityllumazine synthase (lumazine synthase)

5/2010	Virtual screening, selection and development of a benzindolone structural scaffold for inhibition of lumazine synthase.
8/2009	Discovery and development of a small molecule library with lumazine synthase inhibitory activity.
4/2008	A new series of N-[2,4-dioxo-6-d-ribitylamino-1,2,3,4-tetrahydropyrimidin-5-yl]oxalamic acid derivatives as inhibitors of lumazine synthase and riboflavin synthase: design, synthesis, biochemical evaluation, crystallography, and mechanistic implications.
9/2007	Synthesis and enzyme inhibitory activity of the s-nucleoside analogue of the ribitylaminopyrimidine substrate of lumazine synthase and product of riboflavin synthase.
10/2006	Structural and thermodynamic insights into the binding mode of five novel inhibitors of lumazine synthase from Mycobacterium tuberculosis.
3/2005	Crystal structure of lumazine synthase from Mycobacterium tuberculosis as a target for rational drug design: binding mode of a new class of purinetrione inhibitors.

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Markus Fischer Research Topics

Disease

9	Tuberculosis (Tuberculoses) 10/2020 - 03/2005
3	Hypersensitivity (Allergy) 07/2019 - 01/2014
2	COVID-19 01/2022 - 12/2020
2	Infections 09/2019 - 01/2012
2	Communicable Diseases (Infectious Diseases) 01/2017 - 02/2014
2	Malaria 02/2015 - 10/2013
2	Squamous Cell Carcinoma (Epidermoid Carcinoma) 07/2007 - 08/2003
1	Human Influenza (Influenza) 01/2022
1	Virus Diseases (Viral Diseases) 01/2022
1	Hemolysis 01/2022
1	Breast Neoplasms (Breast Cancer) 11/2020
1	Rheumatoid Arthritis 11/2020
1	Squamous Cell Carcinoma of Head and Neck 01/2020
1	Listeriosis (Listeria Infection) 09/2019
1	Rare Diseases (Rare Disease) 09/2019
1	Immune System Diseases (Immune Disorders) 01/2019
1	Spinal Cord Injuries (Spinal Cord Injury) 11/2018
1	Atherosclerosis 01/2017
1	Hemolytic-Uremic Syndrome 11/2016
1	Diarrhea 09/2015
1	Foodborne Diseases 09/2015
1	Inflammation (Inflammations) 12/2014
1	Cardiovascular Diseases (Cardiovascular Disease) 11/2012
1	Long QT Syndrome 11/2012
1	Paraganglioma (Paragangliomas) 04/2009
1	Carcinoma (Carcinomatosis) 07/2007
1	Ganglion Cysts (Ganglion) 02/2002

Drug/Important Bio-Agent (IBA)

6	EnzymesIBA 01/2017 - 02/2002
6	6,7-dimethyl-8-ribityllumazine synthase (lumazine synthase)IBA 05/2010 - 03/2005
3	Pharmaceutical PreparationsIBA 01/2022 - 02/2015
2	Phosphotransferases (Kinase)IBA 11/2020 - 01/2020
2	Terpenes (Terpenoids)IBA 01/2017 - 02/2014
2	HerbicidesIBA 01/2017 - 02/2014
2	Anti-Bacterial Agents (Antibiotics)IBA 08/2009 - 03/2005
2	Riboflavin SynthaseIBA 08/2009 - 09/2007
1	Antiviral Agents (Antivirals)IBA 01/2022
1	remdesivirIBA 01/2022
1	RNA-Dependent RNA Polymerase (RNA Dependent RNA Polymerase)IBA 01/2022
1	favipiravirIBA 01/2022
1	ruxolitinibIBA 12/2020
1	tofacitinibIBA 11/2020
1	Lapatinib (GW572016)FDA Link 11/2020
1	Epoxide HydrolasesIBA 10/2020
1	HydrolasesIBA 10/2020
1	Proto-Oncogene Proteins c-metIBA 01/2020
1	Glucose (Dextrose)FDA LinkGeneric 01/2020
1	Messenger RNA (mRNA)IBA 01/2020
1	tyrosine receptor (receptor, tyrosine)IBA 01/2020
1	GTP Cyclohydrolase (GTP Cyclohydrolase I)IBA 09/2019
1	AntibodiesIBA 07/2019
1	Immunoglobulin G (IgG)IBA 01/2019
1	Immunoglobulin E (IgE)IBA 01/2019
1	EpitopesIBA 01/2019
1	GoldIBA 11/2018
1	LigandsIBA 11/2018
1	Apolipoproteins E (ApoE)IBA 01/2017
1	enterohemolysinIBA 11/2016
1	EmeticsIBA 09/2015
1	Antimalarials (Antimalarial Agents)IBA 02/2015
1	ProdrugsIBA 02/2015
1	SterolsIBA 12/2014
1	Bile Acids and Salts (Bile Acids)IBA 12/2014
1	Mevalonic Acid (Mevalonate)IBA 02/2014
1	AllergensIBA 01/2014
1	fosmidomycinIBA 10/2013
1	Metoprolol (Toprol-XL)FDA LinkGeneric 11/2012
1	Succinate Dehydrogenase (Fumarate Reductase)IBA 04/2009
1	Phosphates (Orthophosphate)IBA 04/2008
1	Schiff Bases (Schiff Base)IBA 04/2008
1	DNA (Deoxyribonucleic Acid)IBA 07/2007
1	Biological ProductsIBA 08/2003

Therapy/Procedure

2	Therapeutics 01/2022 - 11/2012